Antemetic API Ondansetron HCl (146475-23-2)
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Price:
Negotiable
- minimum:
- Total supply:
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Delivery term:
The date of payment from buyers deliver within days
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seat:
Anhui
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Validity to:
Long-term effective
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Last update:
2017-10-11 00:57
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Browse the number:
186
Company Profile
Hefei Reachever Import and Export Limited CompanyBy certification [File Integrity]
Contact:Ms. Beryl(Mr.)
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Phone:
Area:Anhui
Address:Anhui
Website: http://reachever.pulsemotor.net/
Product Details
ANTEMETIC ONDANSETRON HCL
CAS NO 146475-23-2/146844-89-5
MF: C17H19F2N3O3
Standard: BP/EP/USP
ASSAY 98~102%
White or almost white crystalline powder
Slightly soluble in water, very slightly soluble in methanol, practically insoluble in ethano
USE:
Ondansetron hcl is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic, often following chemotherapy. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
CAS NO 146475-23-2/146844-89-5
MF: C17H19F2N3O3
Standard: BP/EP/USP
ASSAY 98~102%
White or almost white crystalline powder
Slightly soluble in water, very slightly soluble in methanol, practically insoluble in ethano
Test items |
Standard |
Test results |
Description |
White or almost white crystalline powder |
white crystalline powder |
Solubilit |
Slightly soluble in water ,very slightly soluble in methanol, practically insoluble in ethano |
Complies |
Identificatio |
IR vs standard |
Complies |
Test for specific optical rotation |
Complies |
|
Appearance of solution |
The solution is clear and colorless |
Complies |
Acidity |
Not more than 0.6ml of 0.01M Naoh is required to change the color of the indicator to pink |
0.44ml |
Specific optical rotatio |
+74.5°~+78.0° |
+75.6° |
Related substances |
ImpurityA:NMT0.1% |
0.03% |
Impurity B: NMT0.1% |
0.05% |
|
Impurity C: NMT0.1% |
0.03% |
|
Any other impurity:NMT0.1% |
0.05% |
|
Total of other impurities:NMT0.1% |
0.06% |
|
Total of impurities:NMT0.3% |
0.16% |
|
Impurity D |
NMT0.1% |
0.01% |
Silver |
NMT5ppm |
<1ppm |
Loss on drying |
NMT0.5% |
0.19% |
Assay |
98~102% (dried substance) |
99.85% |
Bacterial endotoxins |
<1.0IU/mg |
Complies |
USE:
Ondansetron hcl is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic, often following chemotherapy. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
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